- perfringolysin O
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(= theta toxin; q-toxin)Cholesterol binding toxin from Clostridium perfringens. Shares with other thiol-activated haemolysins a highly conserved sequence (ECTGLAWEWWR) near the C-terminus.
Dictionary of molecular biology. 2004.
perfringolysin O
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Cholesterol-dependent cytolysin — Cholesterol Dependent Cytolysins (CDC) are a family of β barrel pore forming exotoxins that are secreted by Gram positive bacteria. CDC are secreted as water soluble monomers of 50 70 kDa, that once bound to the target cell, will form a circular… … Wikipedia
Exotoxin — An exotoxin is a soluble protein excreted by a microrganism, including bacteria, fungi, algae, and protozoa. An exotoxin can cause damage to the host by destroying cells or disrupting normal cellular metabolism. Both gram negative and gram… … Wikipedia
cholesterol binding toxins — Family of 50 60 kD pore forming toxins from various genera of bacteria including Streptococcus, Listeria, Bacillus and Clostridium. Apparently bind to cholesterol and oligomerise to form a pore: as a result cause cell lysis and are lethal. See… … Dictionary of molecular biology
Clostridium — Genus of Gram positive anaerobic spore forming bacilli commonly found in soil. Many species produce exotoxins of great potency, the best known being C. botulinum, and C. tetani. Among the toxins produced by C. perfringens are perfringolysin… … Dictionary of molecular biology
thiol-activated haemolysins — (= oxygen labile haemolysins) Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function.… … Dictionary of molecular biology
PFO — patent foramen ovale; perfringolysin O; plantar fasciitis orthosis * * * patent foramen ovale … Medical dictionary
PFO — • patent foramen ovale; • perfringolysin O; • plantar fasciitis orthosis … Dictionary of medical acronyms & abbreviations
